In the kidney tissue from ADPKD patients, PKD1 mutations lead not only to changes in the biochemical reactions in the mitochondria, but also to a loss in the number of mitochondria in the cells, and the shape of the mitochondria changes from a dense network to a sparse independent individual (Padovano et al. 2018; Ramírez-Sagredo et al. 2021). This evidence concerns the gene PKD1 and autosomal dominant polycystic kidney disease.