PKD1 and autosomal dominant polycystic kidney disease: Due to genetic and allelic heterogeneity, GC-rich regions and the 5′ region of PKD1 (exons 1 to 33) being duplicated in six highly homologous pseudogenes, molecular analysis of ADPKD has proven challenging (Carrera et al. 2016; Phakdeekitcharoen et al. 2001; Rossetti et al. 2002).