PRKCI and renal carcinoma: It is unclear why β1 integrin was not upregulated similarly as α5 integrin with PKCι loss, but this observation could be related to a higher relative abundance of β1 as compared to α5 integrin in renal carcinoma cells, as β1 integrin heteodimerizes more often with other α integrin subunits [38], which can be internalized by different mechanisms (reviewed in [36]).