NOD2 and Crohn disease: One of the initial pieces of evidence came from the autophagy-related 16 like 1 (ATG16L1) study by Hampe et al., who discovered a statistically significant interaction for Crohn's disease risk between rs2241880, a coding SNP (T300A), and established nucleotide-binding oligomerization domain 2 (NOD2) susceptibility variants (P = 0.039) (Hampe et al. 2007).