GWAS has identified hundreds of loci associated with genetic susceptibility of Crohn's disease, including genes involved in innate immunity and bacterial sensing, such as ATG16L1, NOD2, IRGM, LRRK2, STAT3, IL23R, HLA, JAK2, and others (Sazonovs et al. 2022). The gene discussed is NOD2; the disease is Crohn disease.