However, Sun et al. reported that impaired N-myristoylation of LAMTOR1 affects the stability of LAMTOR1 by circumventing its ubiquitination-mediated degradation and altering its lysosomal localization, which is critical for the initiation of autophagy via the mTOR pathway in bladder cancer cells(Sun et al. 2022). The gene discussed is LAMTOR1; the disease is urinary bladder cancer.