The PARP1 pathway has been linked to myocardial alteration, hypertension, and activation of the angiotensin-II pathway, which has a detrimental effect on myocardial tissue activation as a response to ischemia/reperfusion, and on nicotinamide adenine dinucleotide (NAD+), which is involved in cardiomyocyte function in atrial fibrillation, with a cardioprotective effect hypothesized [29]. The gene discussed is PARP1; the disease is atrial fibrillation.