SOD1 and diabetic kidney disease: In the present study, the administration of puerarin could reduce the level of SOD and CAT significantly than those in the DKD group and DKD + irbesartan (40 mg/kg) group, suggesting that puerarin might perform the kidney-protective effect by decreasing the level of oxidative stress in mice, and the effect the puerarin performed was stronger than that of irbesartan.