In the present study, the administration of puerarin could reduce the level of SOD and CAT significantly than those in the DKD group and DKD + irbesartan (40 mg/kg) group, suggesting that puerarin might perform the kidney-protective effect by decreasing the level of oxidative stress in mice, and the effect the puerarin performed was stronger than that of irbesartan. Here, CAT is linked to diabetic kidney disease.