When comparing 4+ to 0-2 organochlroides detected in PD patient’s blood samples, the top 5 hits included hypermethylation of cg09677945 (DNAJC15) and cg15723784 (SMAD3) and hypomethylation cg12456927 (Intergenic), cg02598807 (AP2A2) and cg11667387 (CNNM2). The gene discussed is AP2A2; the disease is Parkinson disease.