When comparing plantation work in blood samples of PD patients, the top 5 hits included hypermethylation of cg25608490 (WNT16), cg08435683 (SLC23A2), cg02286380 (ARRB2) and cg16395997 (WDR8), and hypomethylation of cg12179661 (ENTPD8). This evidence concerns the gene ARRB2 and Parkinson disease.