WFDC2 and metastatic malignant neoplasm in the lymph nodes: Firstly, we found that the serum concentrations of NLR, CA125 and HE4 in OC patients were significantly higher than those in healthy individuals, and the serum concentrations of NLR, CA125 and HE4 were significantly higher in OC patients with advanced stages, lymph node metastases and ascites.