With its pleiotropy in the immune system, IL-10 and its family of cytokines have been widely explored as therapeutic approaches in a wide variety of human diseases involving autoimmunity or excessive inflammation, such as rheumatoid arthritis, psoriasis, and inflammatory bowel disease (Wang et al., 2019; Kwilasz et al., 2015; Tilg et al., 2002; Huynh et al., 2023). Here, IL10 is linked to rheumatoid arthritis.