(3) Inhibiting the TGF-β1 pathway, reducing collagen fiber accumulation, and improving MF (142); (4) Stress on the ventricular wall related to the MF should be reduced, the MF should be improved, the myocardium should be protected, and myocardial ischemia should be improved (143). The gene discussed is TGFB1; the disease is myocardial ischemia.