The different distribution of these baseline data may be since plasma BNP level in children with VSD correlate with QP/QS, mean pulmonary arterial pressure, and pulmonary-systemic vascular resistance ratio (18, 26), and the concomitant increased venous pressure could reduce renal blood flow and urine flow, resulting in elevation of creatinine, TBIL, and DBIL (27, 28). This evidence concerns the gene NPPB and ventricular septal defect.