miR-153 is downregulated in PC tumor tissues and is associated with poor prognosis. Transfection of miR-153 mimics increases apoptosis in GEM-resistant PC cells, an effect that is reversed by Snail overexpression. miR-153 reverses GEM resistance in PC cells by directly targeting Snail. The gene discussed is SNAI1; the disease is pachyonychia congenita.