CRP and Sepsis: Here, we report the integration of bottom-upsynthesized nanoporous graphene onto bimodal waveguide interferometricbiosensors as an atomically precise biofunctionalization scaffold.This combination leverages the high sensitivity of bimodal waveguideinterferometers and the large functional surface area of nanoporousgraphene to create highly sensitive, selective, and robust biosensorsfor the direct immunoassay detection of C-reactive protein (CRP),an inflammatory biomarker widely used in the clinical diagnosis ofinfections and sepsis.