Our results of this paper validated that the expressions of the pro-inflammatory genes (tnf-α and il-1β) and immunoregulatory gene (il-15) increased dramatically at 3.57% or higher dietary glycinin levels, whereas the expression of anti-inflammatory cytokine tgf-β1 was depressed by dietary glycinin, suggesting that excessive dietary glycinin may induce the occurrence of enteritis in hybrid yellow catfish. The gene discussed is IL15; the disease is enteritis.