It should be noted that all C-ARDS patients included in this study were in fact refractory to this steroid therapy, experiencing severe clinical deterioration despite well-conducted treatment, and that in these patients, steroids demonstrated almost a poor biological inhibitory effect on IL-1α, IL-β, IL-6, IL-1Ra or CXCL10 levels (62). Here, CXCL10 is linked to acute respiratory distress syndrome.