CD8A and chronic hepatitis: This was mainly caused by the accumulation of CD8+ T cells in untreated chronic hepatitis (832.6 ± 185.3) compared to control (460.1 ± 122.4, p = 0.0486) and NUC-treated HBV patients (334.4 ± 111.9, p = 0.2199) (Figure 1A).