TP53 and neoplasm: Given the crucial role of transcription factors in driving tumor progression, we identified FOXE1 and TBX18 as being relatively more active in the XPS2 subtype, whereas HNF4A, HNF1A, HNF1B, EPAS1, CEB2, TFE3, and TP53 displayed higher activity in the XPS1 subtype (Figure 3(c)).