We found that classic renal cancer–related genes such as VHL, PBRM1, TTN, and SETD2 had higher mutation frequencies in the TCGA-KIRC cohort, with PBRM1 having a higher mutation rate in XPS1 compared to XPS2 (43% vs. 37%), while mTOR had a lower mutation rate in XPS1 compared to XPS2 (6% vs. 10%) (Figures 6(b), 6(c), and 6(d)). Here, VHL is linked to renal carcinoma.