N = 187. Inclusion criteria: 18 years of age or older, and had no menstrual period in the past 12 months or no menstrual period in the past 6 months with either a medical history of a FSH levels greater than 40 or a bilateral oophorectomy. Self-reporting at least seven hot flashes per day, or 50 hot flashes per week. Exclusion criteria: non-English speakers, concurrent use of other treatments for hot flashes, history of severe psychopathology such as psychosis, borderline personality disorder, or schizophrenia. This evidence concerns the gene BRD2 and schizophrenia.