The results indicating that MYH3, GLUD1, and EPAS1 are protective factors, while WASF2, SQSTM1, SLC7A11, PPM1F, PPIH, NDUFS1, MYH7B, ME1, FLNC, FLNA, DBN1, BOP1, ACTN2, and ACTG2 are risk factors for the prognosis of HBV-HCC patients. The gene discussed is SLC7A11; the disease is hepatocellular carcinoma.