COL6A3 and early-onset generalized limb-onset dystonia: These results are further supported by several previous studies, which reported a significant reduction in right (pre)motor- and left occipital-thalamic structural connectivity in dystonia,16 reduced integrity of cerebellothalamocortical fibre tracts in both clinically manifesting and non-manifesting COL6A3 mutation carriers,53 decreased FA between the bilateral dentate nucleus and thalamus based on probabilistic tractography in patients with autosomal-recessive isolated dystonia (DYT27),54 and fewer thalamic prefrontal connections in patients with idiopathic dystonia.46