BRAF and sinus histiocytosis with massive lymphadenopathy: A study of 23 RDD samples indicated that they were BRAF-V600E wild type, which is consistent with the identification of recurrent BRAF-V600E mutations in ECD, a non-LCH condition [9]. In a similar vein, Chakraborty et al. performed whole-exome sequencing on four RDD patients and found no somatic alterations [17].