In CRRs with significantly elevated IL-6 (up to a 40-fold increase), IL-6 plays a central role in the resulting inflammatory storm of severe hypersensitivity reactions, autoimmune diseases, and infections like COVID-19 (Nepal and Gazeley, 2023; Pelaia et al., 2021; Scott et al., 2023). The gene discussed is IL6; the disease is COVID-19.