In lung cancer, TRIB3 has been reported to facilitate tumor progression by interacting with EGFR (Yu et al., 2020); Similarly, TRIB3 has been shown to enhance the stemness of cancer cells and drive the progression of colorectal cancer and glioma by interacting with β-catenin and TCF4 (Hua et al., 2019; Lu et al., 2020). The gene discussed is TCF4; the disease is central nervous system cancer.