TCF4 and neoplasm: Notably, TRIB3 is key stress regulators in a variety of tumors because its C-terminal domain can interact with ubiquitin ligases and various other proteins to promote tumor progression, such as AKT1, β-catenin, SQSTM1, TRIM8, EGFR, and TCF4 (Xiao et al., 2024; Yu et al., 2019; Zhang et al., 2020).