MAPT and breast cancer: In conclusion, BC and its bioactive constituents, such as Tau, GUDCA, CA, TUDCA, and UDCA, collectively inhibit caspase-9 activation, reduce serum factors permeability coefficient, improve TEER and γ-GT activity, decrease inflammatory factors expression, block the MyD88/NF-κB and P38MAPK pathways, and promote the expression of tight junction proteins such as ZO-1, occludin, and claudin-5.