HFE and hemochromatosis type 1: HFE gene defects (rs1799945 — g.26090951C>G, p.His63Asp, H63D; rs1800562 — g.26092913G>A, p.Cys282Tyr, C282Y; rs1800730 — g.26090957A>T, p.Ser65Cys, S65C) result in hereditary hemochromatosis development (autosomal recessive inheritance), which is characterized by excessive iron absorption that in its turn leads to body intoxication, hepatic cirrhosis, and death [5].