SERPINA1 and chronic obstructive pulmonary disease: SERPINA1 gene (serpin family A member 1, 14q32.13) encodes the protein — alpha-1-antitrypsin, which is synthesized in the liver, bone marrow, lymphoid tissue, intestine; the gene defects result in alpha-1-antitrypsin deficiency (autosomal recessive inheritance) expressed in chronic obstructive pulmonary diseases, emphysema, chronic hepatic diseases [9].