The present study revealed no significant differences in the frequencies of genotypes and alleles of nucleotide sequence variants rs1799945 (H63D), rs1800562 (C282Y), rs1800730 (S65C) of HFE gene, rs113993960 (ΔF508) of CFTR gene, rs28929474 (PIZ), rs17580 (PIS) of SERPINA1 gene between the patients with unconjugated hyperbilirubinemia and the controls. The gene discussed is HFE; the disease is Hyperbilirubinemia.