Another example of FCD related to mTOR disinhibition is polyhydramnios, megalencephaly, symptomatic epilepsy (PMSE) syndrome secondary to biallelic loss of function of STRADA. STRADA forms a complex upstream of the TSC1/2 complex and loss of this pathway leads to unregulated mTOR activity. This evidence concerns the gene STRADA and polyhydramnios, megalencephaly, and symptomatic epilepsy.