Patients with acute osteomyelitis caused primarily by MSSA were given clindamycin or a first-generation cephalosporin for 10 days versus 30 days (first trial) or 20 days versus 30 days (second trial) after an initial IV treatment of 2–4 days in both groups.83 Antibiotics were discontinued with clinical symptom resolution and serum C-reactive protein normalization. This evidence concerns the gene CRP and osteomyelitis.