The authors argued that this reflected higher Aβ production and concluded that the results “unequivocally show that glymphatic clearance alone, without compensation from other clearance mechanisms, would be ineffective in protecting the brain from AD.” In contrast, they interpreted higher levels of tau to suggest greater processing and release during sleep deprivation but not increased production (Barthelemy and others 2020). This evidence concerns the gene MAPT and Alzheimer disease.