CD8A and neoplasm: Interestingly, we did find that the proportion of KR+ TAA-specific CD8+ T-cell trafficking from the tumor to the dLN was significantly reduced after CAN-2409 + prodrug treatment, suggesting that actively responding T cells were retained within the tumor (1.4% ± 0.3% vs. 3.5% ± 0.6%; P = 0.005; Fig. 4G).