CD274 and neoplasm: Indeed, it has been reported that presence of F. nucleatum in CRC correlates with an increased response to ICI therapy, which is suggested to be promoted in an NF-κB and PD-L1-dependent manner.12 Whether F. nucleatum causes an immune-suppressive tumor environment in an ADP-heptose dependent manner and whether this has consequences for ICI therapy remains to be further explored using in vivo models.