CXCL8 and infection: Various lines of evidence exist on the ability of Fusobacterium to induce the release of CXCL8 in different cell lines and types by either bacterial conditioned medium or infection with living bacterial cells.21,31–33 Most studies have been performed using the HCT116 colorectal cancer cell line, which releases CXCL8 after stimulation with living F. nucleatum.