MARCH8, a member of the MARCH family proteins, is part of the RING E3 groups but possesses a unique RING-CH domain, distinguishing it from the classic RING domain.8,27 MARCH8 has been found to be dysregulatly expressed and exert anti-tumor activities in many cancer types, including NSCLC and esophageal cancer.13–15 MARCH8 also reduces the surface expression of ligand receptor 1 (TRAIL-R1) in breast cancer cells,28 indicating the presence of different substrates in a cell context-dependent way. The gene discussed is MARCHF8; the disease is breast cancer.