Immune subtypes were classified into six types, including C1 (wound healing), C2 (IFN-gamma dominant), C3 (inflammatory), C4 (lymphocyte depleted), C5 (immunologically quiet), and C6 (TGF-gamma dominant).24,25Figure 2a illustrated that MARCH8 expression was related to different immune subtypes in most cancers like breast invasive carcinoma (BRCA) and brain lower grade glioma (LGG). This evidence concerns the gene MARCHF8 and cancer.