The World Health Organization classifies medulloblastoma into four distinct molecular subgroups: The new WHO classification for medulloblastoma includes Wingless (WNT)-activated, Sonic Hedgehog (SHH)-activated with TP53 wild type, SHH-activated with TP53 mutation, and non-WNT/non-SHH categories [3]. This evidence concerns the gene SHH and medulloblastoma.