LAP3 and irritable bowel syndrome: In addition, T4 in C1 has also been revealed to have differentially abundant genes for metalloproteases, a family of peptidases previously linked to overactivity in patients with irritable bowel syndrome [102, 103] Meanwhile, the elevated levels of HB metrics in T4 of C2 were unexpected given that reduction of CP in diets has commonly been associated with lower incidence of footpad lesions and better litter quality [104, 105].