A systematic review with meta-analysis reported that in adult people with T1D, liraglutide might be an adjunct to insulin, improving glycemic control, inducing body weight loss, and decreasing exogenous insulin requirements and severe hypoglycemia in people with T1D.In these patients, careful monitoring of blood glucose level or use of continuous glucose monitoring can increase safety of use GLP1RA for treatment of obesity [121]. Here, INS is linked to obesity due to melanocortin 4 receptor deficiency.