Nevertheless, identification of novel associated genes in ALS/FTLD, including TBK1, CCNF, and TIA1, in addition to already known associated-genes in both diseases (SOD1, C9orf72, TARDBP, MAPT, GRN), demonstrates a growing overlap in pathogenic mechanisms underlying both diseases [90]. The gene discussed is TARDBP; the disease is amyotrophic lateral sclerosis.