Thus, dual drugs of oltipraz (an antioxidant drug) and rosiglitazone (a synthetic PPARγ agonist) were encapsulated into the nanomicelle (collagenase/Fab′@iodide@oltipraz/rosiglitazone@PEG-PAE nanoprobes, termed CFIORPP) for the combination therapy of PF. Here, PPARG is linked to pemphigus foliaceus.