KDM5C and acute myeloid leukemia: To further confirm the regulatory effect of KDM5C on CRBN in AML cell lines, we treated THP-1, NB4, and K562 cells with MLN4924.These results were consistent with the data from nonleukemia cell lines showing that MLN4924 increased KDM5C and CRBN in AML cell lines (Fig. 3C–E).