To further confirm the regulatory effect of KDM5C on CRBN in AML cell lines, we treated THP-1, NB4, and K562 cells with MLN4924.These results were consistent with the data from nonleukemia cell lines showing that MLN4924 increased KDM5C and CRBN in AML cell lines (Fig. 3C–E). Here, CRBN is linked to acute myeloid leukemia.