Cancer cells have intricate antioxidant defense systems to neutralize lipid peroxidation and evade ferroptosis, including the cyst(e)ine-GSH-GPX4 (Yang et al, 2014), FSP1-CoQH2/VKH2 (Bersuker et al, 2019; Doll et al, 2019; Mishima et al, 2022), DHODH-CoQH2 (Mao et al, 2021), GCH1-BH4 (Kraft et al, 2020; Soula et al, 2020) pathways and most recently reported the 7-DHC system (Freitas et al, 2024; Li et al, 2024) and the sex hormone-dependent MBOAT1/2 system (Liang et al, 2023), each with distinct subcellular localizations to detoxify lipid hydroperoxides and protect against ferroptosis. This evidence concerns the gene AIFM2 and cancer.