FSP1 functions in parallel to GPX4 to mitigate lipid peroxidation through its NAD(P)H-dependent oxidoreductase activity, which reduces CoQ10 to ubiquinone (CoQH2) or vitamin K to VKH2 (Li et al, 2023), rendering tumors resistant to ferroptosis and representing a promising target to trigger cancer cell death. This evidence concerns the gene AIFM2 and cancer.