This approach revealed a spectrum of steatosis, with normal livers containing some steatotic cells and steatotic livers containing some normal cells, and enabled us to identify CXCL8 as a highly specific and conserved marker of steatotic hepatocytes across normal and steatotic livers (Extended Data Table 1 and Extended Data Fig. 7b). This evidence concerns the gene CXCL8 and steatosis.