Next, we evaluated an IDH-mutant astrocytoma with partial loss of CDKN2A/B (based on methylation-array data; Fig. 6d) demonstrating the highest prediction score for heterozygous deletion of CDKN2A/B across all four biopsies (Fig. 6e,f). Here, CDKN2A is linked to astrocytoma (excluding glioblastoma).