We studied the reactivity of CD4 T cells against Sepsecs, CYP2D6 and PDCE2 in AILD (AIH, PBC and overlap AIH/PBC) patients with or without anti-SLA (SLA+) or anti-LKM1 (LKM1+) or anti-M2 (M2+) autoantibodies. Here, CYP2D6 is linked to primary biliary cholangitis.