Because we hypothesized a close link between circulating autoreactive CD4 T cells and reactive CD4 T cells in the tissue, we established gene module scores based on published datasets of classical TRM CD4 T cells in healthy tissue (lung, skin and intestine)46, CXCL13+ CD4 T cells (TRM-like CD4 T cells) in the liver during Hepatitis B Virus infection (HBV)41 or during Hepatocellular carcinoma (HCC)40 and TPH cell in synovial fluids during autoimmunity30,56 (Supplementary Data 4). Here, CD4 is linked to hepatocellular carcinoma.