HECTD1 and congenital heart disease: A role for HECTD1 variants in human neurobehavioral phenotypes is further supported by a significant enrichment of HECTD1 de novo variants in an independent cohort of 53,305 published trio sequencing cases involving probands diagnosed with either NDDs or congenital heart disease, brain abnormalities in Hectd1 mutant mice, and variable effects of select missense variants in C. elegans models.