Previous studies have confirmed that miR-541-3p is a tumor suppressor, which includes prostate cancer, hepatocellular carcinoma, cervical cancer, etc.16,28,29 It was found that miR-541-3p, a tumor suppressor in NPC, inhibits the downstream gene S100A11 according to this study. This evidence concerns the gene S100A11 and nasopharyngeal carcinoma.