Compared to those with HOMA-IR ≤ 3.06, stage 5 CKD (P = 0.002), BMI, UPCR (P < 0.001), creatinine (P = 0.002), PTH (P = 0.025), and log10 FGF-23 (P = 0.003) were significantly higher in those with HOMA-IR > 3.06, whereas GFR, Ca, P, and 25(OH)VitD3 values were significantly lower (P < 0.001). The gene discussed is FGF23; the disease is chronic kidney disease.