The weight, insulin-like growth factor-1, retinopathy of prematurity algorithm demonstrated a 78.9% sensitivity (95% CI 60.6-97.3), 51.3% specificity (95% CI 45.3-57.3), 10.3% positive predictive value (95% CI 5.3-15.2), and 97.2% negative predictive value (95% CI 94.5-99.9).<h4>Conclusion</h4>ROPScore identified all patients at risk for severe retinopathy of prematurity. Here, IGF1 is linked to retinopathy of prematurity.