AMP-activated protein kinase (AMPK) is a central mediatorof cellularmetabolism and is activated in direct response to low ATP levels.Activated AMPK inhibits anabolic pathways and promotes catabolic activitiesthat generate ATP through the phosphorylation of multiple target substrates.AMPK is a therapeutic target for activation in several chronic metabolicdiseases, and there is increasing interest in targeting AMPK activityin cancer where it can act as a tumor suppressor or conversely itcan support cancer cell survival. The gene discussed is PRKAA2; the disease is neoplasm.