Similarly, many studies examining the effect of AMPK inhibitionhave used compound C which has anticancer effects independent of AMPK.However, there have been recent advances in AMPK inhibitor development;7−9 therefore, it is timely and important to review the current perspectiveof AMPK in cancer and the landscape of direct-acting small moleculeactivators and inhibitors of AMPK. This evidence concerns the gene PRKAA1 and cancer.