RB1 and neoplasm: The synMuv B genes encode homologues of the dREAM complex, which are conserved across animals and plants, including the LIN-35/retinoblastoma (Rb) tumor suppressor, and the Rb complex components LIN-53 /RbAp48, LIN-37/MIP40, LIN-54/MIP120, DPL-1 /DP, LIN-9/MIP130 [16,19–21].