UBE2D4 and retinal degeneration: To this purpose, we expressed human UBE2B (homologous to Ubc6, DIOPT homology score = 13) and human UBE2D2 and UBE2D4 (homologous to eff, DIOPT scores of 13 and 10, respectively) and compared their capacity to rescue retinal degeneration compared to mock mcherry overexpression (Fig 2A).