Aortic stenosis is a leading cardiovascular condition that can cause left ventricular hypertrophy because of sustained pressure overload.1 This structural change, seemingly associated with renin–angiotensin system (RAS) activation, can increase the risk of heart failure and contribute to diastolic dysfunction.2 Transcatheter aortic valve replacement (TAVR) is an effective intervention to treat severe aortic stenosis. Here, REN is linked to aortic stenosis.