Although the role of mosquito saliva in the transmission of Plasmodium is somewhat controversial, recent studies have shown that the Anopheles salivary protein TRIO, expressed exclusively in female mosquitoes’ salivary glands and upregulated in infected mosquitoes (24, 25), influences the local inflammatory response in infected hosts, enhancing Plasmodium motility and infection (26). The gene discussed is TRIO; the disease is infection.